EMD Serono is among key companies with a focus on pioneering research into the multiple pathways involved in
DNA damage response (DDR). Inhibiting these pathways can help disrupt the tumor’s ability to repair damage
and can restore sensitivity to treatments. Our active areas of research include:
The inhibition of DNA-PK, ATR, ATM enzymes to prevent them from coordinating DNA repair, thereby
irreparably driving cell death
Is the DNA damage response pathway a viable target for cancer therapy? This video discusses the key
protein kinases implicated in DDR pathways and the potential implications of inhibition of these
pathways in cancer.